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old man portrait head hand face hair beard wrinkles skin eyes nose mouth expression emotion thoughtful contemplative melancholy sadness grief loss age aging time life death mortality human condition existence soul spirit mind body flesh blood bone muscle sinew organ system function process metabolism growth decay regeneration repair healing disease injury pain suffering anguish agony torture misery despair hopelessness desolation abandonment loneliness isolation alienation estrangement disconnection separation division fragmentation disintegration annihilation extinction