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woman alone house path sunset melancholy isolation loneliness sadness despair hopelessness depression mental health illness sickness disease injury pain suffering anguish misery unhappiness unwell poorly sickly ailing afflicted distressed troubled upset anxious nervous stressed tense panicked hysterical frantic crazy mad insane lunatic psychotic deranged unhinged irrational illogical unreasonable incoherent rambling garbled muddled confused bewildered perplexed puzzled mystified baffled confounded dumbfounded astounded shocked stunned horrified appalled dismayed discouraged disheartened dejected depressed melancholy gloomy morose pessimistic despairing hopeless powerless helpless worthless useless insignificant inconceivable unimaginable unbelievable incredible unfathomable inscrutable mysterious enigmatic puzzling perplexing confusing bewildering disconcerting unsettling disturbing troubling upsetting alarming frightening terrifying horrifying appalling dismaying discouraging disheartening dejecting depressing melancholy gloomy morose pessimistic despairing hopeless powerless helpless worthless useless insignificant