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woman portrait red hair freckles watercolor painting art expression emotion melancholy sadness sorrow grief despair hopelessness torment anguish agony misery suffering pain hurt ache distress trouble tribulation woe lamentation sickness mental illness depression bipolar schizophrenia anxiety stress trauma abuse neglect abandonment betrayal loss grief bereavement sorrow sadness melancholy hopelessness despair emptiness meaninglessness worthlessness guilt shame regret remorse self-loathing self-hatred suicide death dying the end